Retrovir zidovudine, zdv is a drug prescribed for the treatment of the human immunodeficiency virus infection hiv. Consideration should be given to official treatment guidelines for hiv1 infection e. Patients receiving zidovudine retrovir assessment prior to administration obtain complete health history including allergies, drug history and possible drug. Zidovudine is credited with extending the lifespan of many persons with aids. The toxicological effects of this product have not been thoroughly studied. Zidovudine version july 21, 2017 talk to your doctor if you are pregnant or are thinking about becoming pregnant, or if you plan to breastfeed. Lamivudine and zidovudine may decrease the number of certain cells in your blood, including red and white blood cells. Zidovudine fda label capsule, syrup, injection solution. Side effects of retrovir zidovudine, warnings, uses. The most reliable research is summed up for you in our featured article. Zidovudine can be used safely with most other medicines. Caution patient to avoid driving or otheractivitiesrequiringalertnessuntilresponsetomedicationisknown.
It acts by interfering with viral reverse transcriptase, thereby inhibiting human immunodeficiency virus hiv replication. No adverse effects were reported on maternal body weight, food consump. Read more about the prescription drug lamivudinezidovudine oral. Spc is a detailed technical summary that you can access as a pdf file. Except as otherwise noted, this work is licensed under a creative commons attributionnoncommercialshare alike 4. Nov 09, 2018 zidovudine is an antiviral medicine that prevents human immunodeficiency virus hiv from multiplying in your body. Serious side effects of zidovudine include lactic acidosis, liver problems, myopathy, and blood disorders such as severe anemia or neutropenia. Lamivudinezidovudine side effects, dosage, interactions. Retrovir zidovudine tablets, capsules, and syrup label. It is commonly used in pregnancy and appears to be safe for the baby.
Patients who receive both methadone and zidovudine may experience symptoms characteristic of opiate withdrawal and attribute the cause to decreased methadone levels due to zidovudine. Liver function has gotten worse in people who were taking zidovudine injection and interferon alfa with or without ribavirin. Many side effects from hiv medicines, such as nausea or occasional dizziness, are manageable. Adverse effects and treatment strategies during long term art. Various precautions and warnings with zidovudine are listed in this emedtv segment. This is not a complete list of side effects and others may occur. More rarely, it can cause anemia and low white blood cell counts. Lamivudine and zidovudine is a combination medicine used to treat. This includes any possible side effects not listed in this leaflet. Your doctor may temporarily stop your treatment if you experience serious side effects. Lamivudinezidovudine 150 mg pcp 300 mg filmcoated tablets. What are some other side effects of zidovudine injection. It is usually taken at a dose of 300 mg twice daily, with or without food.
Commonly reported side effects of zidovudine include. This includes important information on those who should not take the hiv medication, potentially serious side effects, and things to tell your healthcare provider. Zidovudine zidovudine dose, indications, adverse effects. Patient goals and expected outcomes the patient will. Zidovudine tablets usp 300 mg belongs to a group of antiviral medicines.
However, when used separately, the two drugs can have serious side effects in some patients. Because the fetus is most susceptible to the potential teratogenic effects of drugs during the first 10 weeks of gestation and the risks of therapy with zidovudine during that period are not fully known, women in the first trimester of pregnancy who do not require immediate initiation of antiretroviral therapy for their own health may. Jan 14, 2019 our retrovir zidovudine side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Zidovudine uses, side effects, substitutes, composition.
Indications, dose, contraindications, side effects, interactions, cautions, warnings and other safety information for zidovudine. Commonly reported side effects of lamivudinezidovudine include. If you get any side effects, talk to your doctor or pharmacist. Azt zidovudine, retrovir summary azt is a type of antihiv drug called a nucleoside analogue nuke. Inclusion or absence of a drug label on the aidsinfo site does not imply endorsement or lack thereof by aidsinfo. It is sold both by itself and together as lamivudinezidovudine and abacavirlamivudine. It may be used to prevent mothertochild spread during birth or after a needlestick injury or other potential exposure. Remain free of side effects including numbness, dizziness, confusion, convulsions, chest pain, syncope and rash. Blood problems may require blood transfusions or stopping your medication. Drug interactions can stop your treatment from working or may cause unwanted side effects. Lamivudinenevirapinezidovudine whopar part 4 april 2016. Zidovudine side effects, dosage, interactions drugs.
What you need to know before you take lamivudinezidovudine 3. On ehealthme, you can evaluate side effects and drug interactions from 16 million fda reports. There may, sometimes, be other side effects that are not listed above. It is generally recommended for use with other antiretrovirals. Adverse reactions have been reported during therapy for hiv disease with lamivudine and zidovudine separately or in. Administration capsule, oral solution or intravenous infusion. Adverse reactions have been reported during therapy for hiv disease with lamivudine and zidovudine separately or in combination. The goal of hiv treatment is to reduce the amount of virus in a persons body and prevent destruction of the immune. There may, sometimes, be other sideeffects that are not listed above.
Jan 02, 2020 what are some other side effects of zidovudine injection. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for zidovudine. Lamivudinezidovudine oral combivir side effects, medical. Zidovudine investigated as a drug, mutagen, reproductive effector, and tumorigen. Identification of the substancemixture and of the companyundertaking. What lamivudinezidovudine is and what it is used for 2. Common sideeffects include nausea, fatigue, malaise, and. Learn about the potential side effects of zidovudine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Lamivudinezidovudine, sold under the brand name combivir among others, is a medication used to treat hivaids. Tell your doctor if you have or have ever had a low number of any type of blood cells or any blood disorders such as anemia a lower than normal number of red blood cells or. Side effects of antihiv medications antihiv medications help people infected with hiv lead longer, healthier lives. The most common zidovudine adverse effects are headache and malaise. See actual entry in rtecs for complete information. Serious side effects include liver problems, muscle damage, and high blood lactate levels. Zdv is of the nucleoside analog reversetranscriptase inhibitor nrti class. Like all medicines, this medicine can cause side effects, although not everybody gets them. Zidovudine controls hiv infection but does not cure it. Some side effects may show up in your blood tests, and may not appear until 4 to 6 weeks after you start taking zidovudine. Jul 21, 2017 zidovudine version july 21, 2017 talk to your doctor if you are pregnant or are thinking about becoming pregnant, or if you plan to breastfeed. Dec 05, 2019 some side effects of zidovudine may occur that usually do not need medical attention.
Zidovudine azidothymidine is an inhibitor of hiv and was the first drug used in the. Know zidovudine uses, side effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on we dont support your browser. Emphasize the importance of taking zidovudine as directed even if the patient is asymptomatic, and that this drug must always be used in combination with other antiretroviral drugs. Although zidovudine has no significant effect on the regression of these lesions, it does have antiviral activity in these patients as manifested by a decline in serum human immunodeficiency virus type i antigen. The content of this database of side effects adverse drug reactions is intended for educational and scientific research purposes only. Inform patient that zidovudine does not cure hiv and does not reduce the risk of transmission of hiv to others through sexual contact or blood contamination. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away. Find patient medical information for zidovudine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Risk lists for informed consent national institutes of. Pdf morphological effects of chronic administration of zidovudine. Most of arvs have prominent side effects leading to. These side effects may go away during treatment as your body adjusts to the medicine. Our retrovir zidovudine side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
However, it is more likely patients are actually experiencing zidovudine side effects due to increased levels since zidovudine has no effect on methadone metabolism. Zidovudine is an analogue of thymidine in which the 3hydroxyl group is replaced. Most common side effects are nausea, headache and fatigue usually occur in the first few weeks and resolve. Dosing information, drug interactions, and pregnancy information are included. Common side effects include headache, feeling tired, nausea, diarrhea, and fever. Zidovudine is a dideoxynucleoside analogue of thymidine. Introduction zidovudine or azt azidothymidine is the drug used to delay development of aids acquired immunodeficiency syndrome in patients infected with hiv human immunodeficiency virus.
Common side effects include nausea, fatigue, malaise, and insomnia. Capsule, syrup, injection solution several fdaapproved drug labels may be available for zidovudine. If a child is unable to reliably swallow a retrovir 49 capsule or tablet, the retrovir syrup formulation should be prescribed. Lamivudine and zidovudine are antiviral medications that prevent human immunodeficiency virus hiv from multiplying in your body. Serious side effects of zidovudine include lactic acidosis, liver problems, myopathy.
See the aidsinfo fact sheet on hiv medicines and side effects for more information. Commentary biowaiver monographs for immediaterelease solid. It is now studied and more widely used in combination with other drugs. For commercial use or customized versions, please contact biobyte solutions gmbh disclaimer. Nov 09, 2018 lamivudine and zidovudine are antiviral medications that prevent human immunodeficiency virus hiv from multiplying in your body. It is a combination of two antiretroviral medications, lamivudine and zidovudine. In clinical studies, the most common side effects of zidovudine included vomiting, headaches, and nausea. Maintain balanced nutrition including weight at expected levels. Some side effects of zidovudine may occur that usually do not need medical attention. Pdf on jul 18, 2019, patrick sunday igbigbi and others published morphological effects. Common side effects include headaches, fever, and nausea.
Taking zidovudine tablets usp 300 mg at the same time with medicinal products that are. The most common side effects of azt can include headache, nausea, and loss of appetite. Do not take more or less of it or take it more often than prescribed by your doctor. If you have hepatitis c and hiv, talk with your doctor. Zidovudine national library of medicine pubmed health. Zidovudine has caused severe blood problems including a decrease in red blood cells anemia and white blood cells neutropenia. They occur more frequently in people with advanced hiv disease aids. Pdf zidovudine was the first agent approved for treatment of hiv. If you notice anything unusual and are concerned, contact your doctor.
Zidovudine side effects, dosage, interactions drugs everyday health search. These include hypersensitivity reaction or rash, a buildup of lactic acid in the blood lactic acidosis, liver problems, muscle weakness, and blood disorders, such as extremely reduced numbers of red blood cells severe anemia or reduced numbers of white blood cells neutropenia. These sideeffects are usually mild in children taking zidovudine, but if you are worried about any of them, contact your doctor. Zidovudine 100 mg capsules, hard zidovudine 250 mg. Aidsinfo provides the following drug label solely as an example of the labels available for zidovudine. This study is created by ehealthme based on reports of 9,320 people who have side effects when taking zidovudine from food and drug administration fda, and is updated regularly. Know zidovudine uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on we dont support your browser. However, many people have no side effects or only have minor side effects. Call your doctor for medical advice about side effects. Azt belongs to a group of drugs known as nucleoside reverse t. Do not take more than prescribed amount, and do not stop taking without consulting health care professional.
Zidovudine or azt azidothymidine is the drug used to delay development of aids acquired immunodeficiency syndrome in patients infected with hiv human immunodeficiency virus. These side effects are usually mild in children taking zidovudine, but if you are worried about any of them, contact your doctor. Zidovudine uses, side effects, substitutes, composition and. If any of the side effects gets serious, or if you notice any side effects not listed in this. Zidovudine zdv, also known as azidothymidine azt, is an antiretroviral medication used to prevent and treat hivaids. Zidovudine tablets usp 300 mg should not be taken in combination with stavudine or ribavirin. Jan 20, 2020 zidovudine can cause serious, lifethreatening side effects. Nov 18, 2019 because the fetus is most susceptible to the potential teratogenic effects of drugs during the first 10 weeks of gestation and the risks of therapy with zidovudine during that period are not fully known, women in the first trimester of pregnancy who do not require immediate initiation of antiretroviral therapy for their own health may.
Zidovudine 100 mg capsules, hard zidovudine 250 mg capsules, hard. What are some other side effects of lamivudine and zidovudine. There are also a number of potentially serious side effects that should be reported to a healthcare provider right away, such as any signs of liver problems, unusual bleeding or. Zidovudine definition of zidovudine by medical dictionary. Find information on zidovudine retrovir in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Azt belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors nrtis.
Zidovudine also known as azt injection is used in combination with other antivirus medicines in the treatment of the infection caused by the human read more. The following side effects have been associated with use of zidovudine. Decrease in the number of white blood cells that help fight infection decrease in the number of red blood cells that may cause weakness, dizziness, and fatigue muscle aches, weakness, and wasting headache. Zidovudine is an antiviral medicine that prevents human immunodeficiency virus hiv from multiplying in your body. Only select registry of toxic effects of chemical substances rtecs data is presented here. Zidovudine is the first drug approved for the treatment of hiv infection and is still in the part. It is likely that the adverse effects of zidovudine as. Zidovudine tablets usp 300 mg may also interact with valproic acid, fluconazole and probenecid making side effects worse.
Nursing considerations the abbreviation azt has also been used for another medication. Tell your doctor if you have any serious side effects of retrovir including. Consumer information about the medication lamivudinezidovudine oral combivir, includes side effects, drug interactions, recommended dosages, and storage information. Side effects include nausea, weight loss, insomnia, diarrhea, and severe headache. A wide range of drugs interact with zidovudine, either increasing its adverse effects or reducing its effectiveness. See below for a comprehensive list of adverse effects. A small percentage of patients require a decrease in dosage to alleviate these complaints. If you get any of these effects, and if they are severe, your doctor may advise you to stop taking zidovudine. Improved safety, bioavailability and pharmacokinetics of zidovudine.
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